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Concurrent Training and Nutritional Management in Cancer

Concurrent Training and Nutritional Management Prevent Body Weight Loss During Radiotherapy in a Young Adult With Head and Neck Cancer: A Case Control Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03720015
Enrollment
1
Registered
2018-10-25
Start date
2017-07-20
Completion date
2017-09-17
Last updated
2018-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Weight Changes

Brief summary

A case control study with before-after design. A concurrent training and a nutritional management intervention was offered by a patient with head and neck cancer, in order to compare outcomes related to strength and endurance performance and to body composition

Detailed description

Cancer causes important public health problems around the world and it is one of the most frequent cause of death overall. Among non-pharmacological treatment, physical exercise has shown improvements in different types of cancer and patients, but it is important to define the optimal dose. Our aim is to determine the effects of a concurrent training program and a nutritional management developed during radiotherapy treatment on physical performance and body composition. A patient with an oral cavity cancer will develop three sessions per week of concurrent training: resistance training included 9 standard exercises involving major muscle groups (4x8-12 RM), and cardiovascular training included a High-Intensity Interval Training (HIIT). Nutritional management will include a diet controlling macronutrients (\ 4g/kg/day for carbohidrates, \ 2g/kg/day for proteins, and \ 1g/kg/day for fats), along with some nutritional supplements such as beta-hydroxybeta-methylbutyrate (HMB), arginine, glutamine, omega-3 fish oil concentrate, and BCAA's during training sessions. Intervention took place during radiotherapy period (7 weeks). We expect that body composition will remain invariable, and 1RM will increased. VO2max is expected to be almost the same, but intensity tolerated at maximum VO2max could be higher. If our results confirm that, we could conclude that a combination between resistance exercise and HIIT along with a nutritional management developed during radiotherapy could be effective to prevent muscle mass loss and muscle function decrease in a young patient with oral cavity cancer.

Interventions

BEHAVIORALPhysical exercise

Physical exercise controlled program supervised by an accredited exercise specialist

DIETARY_SUPPLEMENTNutritional management

Nutritional management controlled by a PhD clinical and sport nutrition specialist

Sponsors

Universidad Francisco de Vitoria
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

Case study

Eligibility

Sex/Gender
MALE
Age
32 Years to 34 Years
Healthy volunteers
No

Inclusion criteria

This is a case control study

Design outcomes

Primary

MeasureTime frame
Body weight in kilograms (kg)8 weeks
Visceral adipose tissue in cm28 weeks
Total fat in percentage (%)8 weeks
Lean body mass in percentage (%)8 weeks

Secondary

MeasureTime frameDescription
1 repetition maximal (1RM) for upper-body in kilograms (kg)8 weeksTest will be performed in vertical bench press
1 repetition maximal (1RM) for lower-body in kilograms (kg)8 weeksTest will be performed in leg press
Maximal oxygen uptake (VO2max) in ml/kg/min8 weeksTest will be performed in a cycloergometer
Power at VO2max in watts (W)8 weeksTest will be performed in a cycloergometer

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026