Hysterectomy
Conditions
Brief summary
Our study will compare the rates of postoperative urinary tract infections (UTI) between patients who undergo cystoscopy using 50% dextrose injection plus bladder washout versus normal saline after hysterectomy for benign indications. Primary outcome will be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter.
Detailed description
This will be a prospective cohort study of the rate of UTIs after cystoscopic distention media of normal saline with maximum injection of 40 cc of 50% dextrose plus 300 cc of normal saline washout versus normal saline after hysterectomy for benign indications. A pre-operative urine culture will be obtained via mid-stream clean catch prior to administration of routine pre-operative prophylactic antibiotics. At 6-9 days post-operatively, a repeat urine culture will be obtained via mid-stream clean catch. Appropriate treatment will be administered if the urine culture is positive.Primary outcome will be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter.
Interventions
PROCEDURE50% dextrose
maximum injection of 40 cc of 50% dextrose plus 300 cc of normal saline washout versus normal saline after hysterectomy for benign indications.
PROCEDURENormal Saline
Cystoscopic distention media of normal saline
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Masking description
Participant masked to distention media
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Preoperative scheduling CPT codes for hysterectomy
Exclusion criteria
* Discharged home with indwelling foley catheter * Indwelling foley catheter \> 24 hours * Ureteral injury * Chronic immunosuppression * History of diabetes * Recurrent UTIs (≥2 infections in six months or ≥3 infections in one year) * Reported Chronic Kidney Disease * Renal anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rates of urinary tract infections at 6-9 days post-operative | 6-9 days post-operative | be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter |
Countries
United States
Outcome results
None listed