Biliary Tract Cancer
Conditions
Brief summary
The purpose of this study is to investigate genetic mutations affecting prognosis using whole genome sequencing in patients with biliary tract cancer.
Detailed description
Recently, as genome technology such as next-generation sequencing has progressed, precision medicine using genetic analysis in lung cancer, colorectal cancer, and melanoma has been actively studied. The need for such precision medicine is also increasing in biliary tract cancer patients. Although whole genome sequencing is relatively costly, it is known to provide more accurate information than other methods such as exome analysis and RNA sequencing in identifying promoter mutations, regulatory regions, and structural variants. Pancreatic cancer and melanoma have been studied by whole genome sequencing, but there is no previous study using whole genome sequencing method in biliary tract cancer.
Interventions
DIAGNOSTIC_TESTEndoscopic retrograde cholangiopancreatogram
Biopsy specimens are attained via endoscopic retrograde cholangiopancreatogram in patients with suspicious biliary tract cancer.
Sponsors
Ji Kon Ryu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with biliary tract cancer via endoscopic retrograde cholangiopancreatogram
Exclusion criteria
* Pregnancy * Other active tumors within 5 years * Coagulopathy * Severe mental illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival rate | 48 months | Comparisons of overall survival rates between patients with gene mutations and without. |
Countries
South Korea
Contacts
Primary ContactMin su You, MD
Backup ContactJi Kon Ryu, MD, phD
Outcome results
None listed