Borderline Personality Disorder
Conditions
Brief summary
The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants undergo assessments at four points (intake, 2 months, discharge and 12 month follow-up). In addition to symptom measures, all individuals undergo a two-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): a) behavioural and b) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. The present study uses an innovative treatment of BPD and at the same time a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and sociocognitive processing in brief treatments. It will help increase the effectiveness of initial treatment phase for BPD and help diminish the societal burden of disease related with BPD. This study is funded by the Swiss National Science Foundation (SNSF).
Interventions
BEHAVIORALGood Psychiatric Management - Brief
specific interventions as defined by Gunderson and Links (2014)
BEHAVIORALtreatment as usual
non-specific intervention
Sponsors
University of Lausanne Hospitals
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Borderline Personality Disorder * age between 18 and 35
Exclusion criteria
* non-mastery in French * neurological disorders * schizophrenia (according to DSM-5)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ZAN-BPD (Zanarini Borderline Personality Disorder Scale; Zanarini, 2003) | 4 months | measures borderline symptomatology from an dimensional perspective, ranges between 0 and 36 (36 being the most symptomatic), global score (sum of all 9 items coded between 0 and 4) used. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| OQ-45 (Outcome Questionnaire-45.2, Lambert et al., 2004) | 4 months | measures the level of problems (distress, social and interpersonal) on a scale ranging from 0 to 180 (45 items coded between 0 and 4, 4 being the most symptomatic). A total sum score will be used |
| BSL-23 (Borderline Symptom List, Short Version; Bohus et al., 2009) | 4 months | measures the intensity of borderline symptoms using a mean score of the 23 items ranging between 0 and 4 (4 being the most symptomatic), the mean score will be used. |
Countries
Switzerland
Outcome results
None listed