Graft Failure, Stem Cell Transplant Complications
Conditions
Brief summary
Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for graft failure is far from satisfactory. We performed a prospective single-arm study to investigate the safety and efficacy of a novel regimen.
Interventions
1. Change another donor 2. conditioning regimen: FLU/CY/anti-CD25 moAb
Sponsors
Peking University People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* graft failure after first allogeneic stem cell transplantation * no active infection or GVHD or severe organ dysfunction * sign written informed consent
Exclusion criteria
* active infection, GVHD, organ failure * expected life \< 28 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| engraftment | 28 days after second transplantation | Engraftment of neutrophils was defined as the first of 3 consecutive days when the absolute neutrophil count achieved 500/uL. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TRM at 28 day | 28 days after second transplantation | treatment-related mortality(TRM) was defined as death from any cause other than relapse. |
| TRM at 100d | day 100 after second transplant | treatment-related mortality(TRM) was defined as death from any cause other than relapse. |
| Overall survival at 100d | day100 after second transplantation | Overall survival at 100d |
Countries
China
Contacts
Primary ContactYUQIAN SUN
Outcome results
None listed