The Effect of 10-Week Exercise Training on Children With Asthma

Exercise Training in Children and Adults: Mechanisms of Allaying Inflammation in Asthma

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03716219

Enrollment

Registered

2018-10-23

Start date

2013-10-10

Completion date

2013-10-10

Last updated

2021-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma in Children

Brief summary

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Interventions

OTHERExercise Training

Physical activity in children and adults with asthma.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

8 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Good health * Physical activity * No evidence of disease or disability * Diagnosed with persistent asthma (asthma subjects) * BMI\<95 percentile

Exclusion criteria

* Use of illegal drugs or alcohol * Very high physical fitness * Pregnancy * More than two asthma attack per week (asthma subjects)

Design outcomes

Primary

Measure	Time frame	Description
Gene and microRNA expression will be compared between healthy and asthmatic subjects	12 weeks	Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls

Secondary

Measure	Time frame	Description
Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups	12 weeks	Absolute values of cytokines, growth hormones, and other biomarkers will be measured by flow cytometry and statistically analyzed.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026