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Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance

Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03713788
Enrollment
34
Registered
2018-10-22
Start date
2016-05-01
Completion date
2016-11-30
Last updated
2018-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Stretching Exercises, Pain Threshold

Keywords

Stretch tolerance, Range of Motion

Brief summary

This study investigates the influence of a remote, painful stimulus on stretch tolerance. Half of the participants will receive a conditioning painful stimulus following static stretching while the other half will rest quietly.

Detailed description

The effect of stretching on joint range of motion is primarily related to changes in the tolerance to stretch, but the mechanisms underlying this change are still largely unknown. The nervous system has an inbuilt ability to modulate the perceived magnitude of afferent noxious stimuli via supraspinally mediated endogenous pain inhibition or facilitation and by engaging endogenous mechanisms pain tolerance in healthy individuals is known to increase. Thus increasing the tolerance to pain could potentially increase range of motion following stretching.

Interventions

OTHERCold pressor test

Participants placed their non-dominant hand into cold water for 2 minutes

Sponsors

Aalborg University
CollaboratorOTHER
University College of Northern Denmark
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

A sample of convenience was recruited for this cross-sectional study. Participants were randomly assigned to a pain group or a control group using counterbalanced block randomization. Passive knee extension range of motion was measured three consecutive times with five-minute intervals between measurements. Both groups underwent a static stretch protocol consisting of two bouts of thirty-second constant-angle static stretching of the knee flexors with a one-minute rest between bouts. Subjects were instructed to keep the limb relaxed as the lower leg was passively moved towards extension. Following stretching, the post-stretch measurement was performed. Finally, subjects in the pain group were instructed to immerse their non-dominant hand into a container with circulating water at 1˚C to 4˚C and keep it there for 2 minutes. A Biodex system 4 pro dynamometer was used to quantify range of motion and passive resistive torque. Muscle activity was recorded as surface electromyography.

Eligibility

Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

Exclusion criteria

* Substance abuse, * History of neurological or mental disabilities * Lack of ability to comply with instructions * Delayed onset of muscle soreness.

Design outcomes

Primary

MeasureTime frameDescription
Knee extension range of motionPassive knee extension range of motion was measured at baselinePassively induced knee extension range of motion was measured usind the Biodex system 4 pro isokinetic dynomometer
Change in knee extension range of motion between baseline and post stretch.Changes in passive knee extension range of motion were measured 5 minutes after baseline measures following stretchingChanges in passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynomometer
Changes in knee extension range of motion between post stretch and post pain.Changes in passive knee extension range of motion were measured 5 minutes after post stretch measures following intervention.Changes in passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynomometer

Secondary

MeasureTime frameDescription
Passive resistive torque using the Biodes system 4 pro.Passive resistive torque during the passive knee extension motion was measured at baseline.Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.
Surface electromyography measures of muscle activityMuscle activity during the passive knee extension motion was measured at baselineMuscle activity during the passive knee extension motion were measured using SEMG.
Changes in passive resistive torque measured using the Biodex system 4 pro between post stretch and post pain measures.Passive resistive torque during the passive knee extension motion was measured 5 minutes after post stretch measures following intervention.Changes in Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.
Changes in passive resistive torque measured using the Biodex system 4 pro between baseline and post stretch measures.Changes in passive resistive torque during the passive knee extension motion was measured 5 minutes after baseline measures following stretching.Changes in passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.
Changes in surface electromyography measures of muscle activity between baseline and post stretch measures.Changes in muscle activity during the passive knee extension motion were measured 5 minutes after baseline measures following stretching.Changes in muscle activity during the passive knee extension motion were measured using SEMG.
Changes in surface electromyography measures of muscle activity between post stretch and post pain measures.Changes in muscle activity during the passive knee extension motion were measured 5 minutes after post stretch measures following intervention.Changes in muscle activity during the passive knee extension motion were measured using SEMG.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026