Anesthesia, Fluid Responsiveness
Conditions
Keywords
Fluid Responsiveness, Anesthesia, Surgery, Stroke Volume Variation, Fluid status,
Brief summary
Proper identification of patients who would benefit from fluid infusion (fluid responsiveness) is one of the most crucial challenges in anaesthesia and critical care. Reliability of several invasive measurements used for this purpose for many years have been questioned recently. The study will evaluate consistency between carotid artery flow derivatives and standard haemodynamic measurement (LIDCO rapid) in navigation of intraoperative fluid therapy.
Interventions
DIAGNOSTIC_TESTFluid bolus
All patients included in the study will receive 5 ml/kg fluid bolus of a balanced crystalloid solution.
Sponsors
Medical University of Warsaw
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
All patients included in the study will receive 4 ml/kg fluid bolus.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Major abdominal surgery * Artery catheter required
Exclusion criteria
* Laparoscopic surgery * Known history of carotid endarterectomy * Known history of carotid stenosis * Non-sinus rhythm * Systolic or diastolic heart failure * Chronic kidney disease * Pulmonary hypertension * Carotid artery anomaly * Unable to visualise carotid artery * Angle of correction \> 60
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cardiac output | Before and 2 minutes after intervention | A measure of change of scaled cardiac output (nCO) with LiDCO device |
| Change in a corrected carotid artery flow | Before and 2 minutes after intervention | Ultrasound measure of corrected carotid artery flow time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in pulse pressure variation | Before and 2 minutes after intervention | A measure of change of pulse pressure variation (PPV) with LiDCO device |
| Change in stroke volume variation | Before and 2 minutes after intervention | A measure of change of pulse pressure variation with LiDCO device |
| Change in a carotid blood flow | Before and 2 minutes after intervention | Ultrasound measure of corrected carotid blood flow time |
| Change in a velocity time integral of carotid flow | Before and 2 minutes after intervention | Ultrasound measure of velocity time integral of carotid flow |
| Change in the maximal systolic carotid velocity variation | Before and 2 minutes after intervention | Ultrasound measure of the maximal systolic carotid velocity variation |
Countries
Poland
Outcome results
None listed