Thyroxin in Subclinical Hypothyroidism

Prevalence of Subclinical Hypothyroidism in Women With Unexplained Infertility and the Effect of Thyroxin on Pregnancy Rate

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03712683

Enrollment

168

Registered

2018-10-19

Start date

2016-09-01

Completion date

2017-07-01

Last updated

2018-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sub Clinical Hypothyroidism, Pregnancy Loss

Keywords

Unexplained Infertility, pregnancy rate,hypothyroidism

Brief summary

Subclinical hypothyroidism(SCH) is the elevated thyroid stimulating hormone (TSH) with normal free Thyroxine levels and it is a mild or compensated form of primary hypothyroidism. It has been suggested that SCH is more prevalent in infertile women (especially in women with ovulatory disorders.Various rates of SCH was reported in infertile women in different populations

Detailed description

Despite well-established recommendations on screening and treatment of overt hypothyroid in infertile women, there is a controversy regard the treatment of SCH in infertile women . There are few published data on the prevalence of SCH and the outcome of treatment of SCH in infertile women, many were conducted during IVF cycles . Moreover there are inconsistent results in these studies being authors advised to treat SCH before IVF and some other articles find out no any benefit regarding treatment with Thyroxine in SCH

Interventions

DRUGThyroxine

Thyroxine was prescribed with the diagnosis of SCH and continued when pregnancy was confirmed

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 42 Years

Healthy volunteers

Inclusion criteria

1. Unexplained infertility 2. TSH more than 2.5 and normal T3,T4 levels 3. Negative for Anti-thyroid antibodies

Exclusion criteria

1. current history of overt hypo or hyperthyroidism 2. recurrent pregnancy loss 3. women having franked causes for infertility like tubal blockage, pelvic inflammatory disease, endometriosis , ,uterine factor 4. Ovarian dysfunction or decreased ovarian reserve 5. abnormal seminal fluid analysis or male factor

Design outcomes

Primary

Measure	Time frame	Description
Pregnancy	2 years	Pregnancy was confirmed using human chorionic gonadotropin hormone (hCG) estimation from blood

Secondary

Measure	Time frame	Description
Miscarriage rate	13 weeks	viability and growth of embryos were confirmed by ultrasound

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026