Abdominal Acupuncture, Brain Ischemia, Electrophysiology of Neuromuscular, Hemiplegic Patients With Stroke, Image Science
Conditions
Keywords
Functional magnetic resonance imaging（fMRI）, Surface electromyography （sEMG）, Abdominal acupuncture, Brain Plasticity, Effects and mechanism
Brief summary
Using random number method to categorize the selected first onset patients with stroke who meet the inclusion criteria into 3 groups.The patients were randomly divided into treatment group A(abdominal acupuncture+upper limb rehabilitation training, 22 cases), treatment group B(Sham abdominal acupuncture+upper limb rehabilitation training, 22 cases),and control group(upper limb rehabilitation training, 22 cases). SEMG and fMRI examination and related stroke rehabilitation assessment scales were evaluated before and after treatment.
Interventions
Abdominal acupuncture treatment method: 1.Acupoints selection :Zhongwan,Xiawan,Shangqu,Qihai,Guanyuan,Huaroumen,Upper rheumatic and Upper rheumatic external points etc.(Acupoints selection referred to Abdominal Acupuncture Therapy written by Bo Zhiyun ,the founder of Abdominal Acupuncture. 2.Treatment Duration: 30 minutes a session, once a day, 5 times a week for 3 weeks.
OTHERSham abdominal acupuncture
Sham abdominal acupuncture Abdominal acupuncture treatment method: 1.Acupoints selection and treatment duration are the same as abdominal acupuncture. 3.Method：Using the sham abdominal acupuncture needles were produced by DONGBANG AcuPrime Acupuncture Instrument Co., Ltd. ( U.K.)The tip of the needle was exposed to 1mm of the cannula. The acupoint skin of patients was touched gently by the tip, and the tip of needle was lifted and removed from acupoint skin after 30s. Rest for 30 seconds ,then repeated 6 times, a total time of stimulation is 6min.
Sponsors
Chinese University of Hong Kong
Guangzhou University of Traditional Chinese Medicine
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. First onset stroke, Left hemiplegia, Right-handed，and diagnosed by brain CT or MRI; 2. Age 35 to 75 years old; 3. Course of disease 0.5 to 3 months with stable vital signs; 4. No cognitive impairment. Can understand and execute commands. MMSE score more than 7 points. ; 5. Can control the sitting balance. Brunnstrom stage of hemiplegic upper limb and hand is Ⅳ or V ，Fugl-Meyer Motor Assessment score of upper limb 20-50 point; 6. Agree to sign the informed consent; 7. Unilateral neglect.
Exclusion criteria
1. Recurrent stroke，subarachnoid hemorrhage, brain tumors patients; 2. Contraindication to undergo a 3T MR imaging; 3. Claustrophobia; 4. Have severe heart, hepatic or renal failure; 5. Don' t cooperate with the treatment; 6. Have participated in other clinical trails recently.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Motor function of muscles | SEMG will be tested before and after 4 weeks treatment,twice totally. | Common measures of sEMG will be tested. See the study protocol for details. |
| The integrity of the corticospinal tract | Diffusion tensor imaging(DTI) will be tested before treatment and 4 weeks after treatment,twice totally. | The integrity of the corticospinal tract will be tested by diffusion trnsor imaging(DTI) of craniocerebral functional magnetic resonance imaging examination using magetic angiography to measure the changes caused by neuronal activity.We will observe the shape and integrity of the corticospinal tract. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wolf Motor Function Test | Before treatment, 2 weeks and 4 weeks after treatment， 3 times totally. | See the study protocol for details |
| Brunnstrom staging of upper limb movement | Before treatment, 2 weeks and 4 weeks after treatment， 3 times totally. | See the study protocol for details |
| Fugl-Meyer Motor Assessment of upper limb | Before treatment, 2 weeks and 4 weeks after treatment， 3 times totally. | See the study protocol for details |
| Modified Barthel Index，MBI | Before treatment, 2 weeks and 4 weeks after treatment， 3 times totally. | See the study protocol for details |
Countries
China, Hong Kong
Contacts
Primary ContactHongxia Chen, Master
Backup ContactRuihuan Pan, Doctor
Outcome results
None listed