Pneumonia
Conditions
Keywords
Serial Procalcitonin, Admitted Pneumonia, qSOFA, Sepsis
Brief summary
Procalcitonin levels checked initially and at 24 hours will correlate with disease severity, morbidity, and mortality. Patients who have a higher procalcitonin level initially and at 24 hours will likely have higher qSOFA scores, longer lengths of stay, longer duration of antibiotics and higher 30 day mortality rates.
Detailed description
A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level, much like the current initial and 4 hour lactate orders are set-up. These patients will receive treatment for their pneumonia as is deemed appropriate by their care teams, both in the Emergency Department and while an inpatient. Then, after discharge, the 30 day mortality, length of stay, choice of antibiotic therapy, and qSOFA score (which will be retroactively calculated) will be compared to the patient's initial and 24 hour procalcitonin level.
Interventions
DIAGNOSTIC_TESTProcalcitonin lab test
A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level.
Sponsors
Michigan State University
Corewell Health South
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients seen at Lakeland St. Joseph and Niles Hospitals in the emergency department and who are then subsequently admitted with pneumonia at Lakeland St. Joseph and Niles Hospitals
Exclusion criteria
* Any patients not admitted with pneumonia, any patients who are admitted with another primary diagnosis other than pneumonia, any patients who do not have an initial or 24 hour procalcitonin level result, and any patients less than 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Procalcitonin level | Measured at baseline and at 24 hours | Change in procalcitonin level in the blood serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| qSOFA score | baseline and at 24 hours | qSOFA score is based on blow blood pressure, high respiratory rate, and altered mental status |
| Length of stay | an average of 30 days | Length of stay in days, total stay from admission until discharge |
| Duration of antibiotics | an average of 30 days | Antibiotic treatment length in days |
| 30 Day Mortality | 30 days | Number of patients who expire vs those alive at 30 days |
Countries
United States
Outcome results
None listed