Major Depressive Disorder, Bipolar Disorder, Suicide
Conditions
Keywords
eye-tracking, eye movement, saccade
Brief summary
This research tries to investigate the validity and reliability of eye-tracking technologies by using different paradigms (eg. free-view, pro-saccade and anti-saccade) which served as a novel way of evaluating suicide risk among affective disorder patients including bipolar and unipolar depression. All the participants including health control will be assessed by clinical interviewing, self-report assessment, cognitive evaluation and eye-tracking task.
Interventions
BEHAVIORALeye-tracking
After completing a demographics form, theBeck Depression Inventory,Beck Anxiety Inventory,Barratt Impulsiveness Scale and Ruminative Response Scale-21, each participant has to go to the eye-tracking room and seats in a height adjustable chair and places their chin in a chin rest which was positioned to make sure all participants' eye are in the same location relative to the camera and the monitor. There are 18 trials and 2 filler trials in the free-view task, each of which contains 4 pictures on the same screen for 25 seconds. There is also a gap screen between each trial lasting for 2 seconds when participants were asked to fixate in the center of the screen. During the experiment, participants are instructed to watch the screen as naturally as possible, and the initial location of the fixation of each trial and the total dwell time of each emotional images(negative, happy, neutral and suicide-related)and the changes of the pupil size were recorded.
Sponsors
Central South University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
12 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnostic and Statistical Manual,DSM-IV diagnosis of depression or Bipolar disorder * BDI-II\>20(Suicide and disorder control group); BDI-II\<13，no history of depression(Health control) * Informed consent * suicide attempt in the past 6 months(suicide risk group)
Exclusion criteria
* Current or past substance abuse, psychotic disorder,obsessive compulsive disorder , Post-Traumatic Stress Disorder, in the past 6 months * History of epilepsy or head trauma * Eye disorders * History of electroconvulsive therapy in the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| eye movement performance during free-view task | 1 hour | The first fixated location and latency(msec)of eah trial, the total dwell time(msec) in each interest areas(IAs) during the whole trial to assess the attentional bias in the experiment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scores in self-report assessment:Beck Depression Inventory | 5 minutes | This scale is aimed to assess the clinical depressive symptom in the recent 7 days. |
| Scores in self-report assessment:Beck Anxiety Inventory | 5 minutes | This scale is aimed to assess the clinical anxieous symptom in the recent 7 days |
| Scores in self-report assessment:Barratt Impulsiveness Scale | 5 minutes | This scale is aimed to assess participant's impulsive trait. |
| Scores in self-report assessment:Ruminative Response Scale | 5 minutes | This scale is aimed to assess participant's ruminative thinking process. |
Countries
China
Contacts
Primary ContactLi Lingjiang, MD Ph.D.
Outcome results
None listed