Type 2 Diabetes
Conditions
Keywords
insulin, drug naive
Brief summary
A multi-centre, open-label trial to investigate the efficacy and possible mechanism of Continuous Subcutaneous Insulin Infusion treatment in patients with drug naive type 2 diabetes.
Interventions
DRUGInsulin
Continuous Subcutaneous Insulin Infusion
Sponsors
Zhejiang Provincial People's Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
for type 2 diabetes: 1. Male or female age ≧ 25 years and ≦75 years old 2. HbA1c ≧8.0% 3. durg naive for normal controls： 1. Male or female age ≧ 25 years and ≦75 years old 2. Normal glucose tolerance confirmed by oral glucose tolerance test
Exclusion criteria
1. Islet antibody positive 2. Athletes, has a history of skeletal muscle injury ( trauma or surgery ), skeletal muscle wasting diseases ( such as mitochondrial myopathy, muscular atrophy, etc ) 3. Acute infection(such as cute upper respiratory infection, acute pneumonia) 4. long-term use of non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressive drugs 5. consists with other endocrine diseases 6. pregnancy 7. cancer 8. use of antibiotics in 3 months 9. chronic digestive inflammations 10. magnetic resonance imaging contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Circulating immunity cell profiles | 7 days | profiles of circulating immunity cells such as T cells |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| skeletal muscle parameter | 7 days | skeletal muscle parameters in magnetic resonance imaging |
Other
| Measure | Time frame | Description |
|---|---|---|
| fasting blood glucose | 7 days | fasting blood glucose |
Countries
China
Outcome results
None listed