Metabolic Syndrome, Overweight and Obesity
Conditions
Keywords
Cardiometabolic Health, Cardiorespiratory Fitness, Muscular Strength, Body Composition, Inflammation, Aerobic Exercise, Resistance Exercise
Brief summary
The main purpose of this study is to compare the impact of concurrent high-intensity interval training (HIIT) and whole-body electromyostimulation exercise (WB-EMS) or low-volume conventional strength training (CST) on the cardiometabolic risk profile, overall physical fitness (cardiorespiratory fitness and muscular strength), body composition, inflammatory markers and subjective health outcomes after a 12-week intervention trial in overweight individuals at increased cardiometabolic risk. Furthermore, this study aims to investigate the influence of intra-session exercise order on all outcomes.
Interventions
OTHERHIIT + WB-EMS
12-week supervised exercise program consisting of ergometer-based high-intensity interval training (HIIT) and whole-body electromyostimulation (WB-EMS). HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. WB-EMS: Simulanteous stimulation of all major muscle groups with dedicated individual intensity. 2 exercise sessions per week. Order of application: HIIT - WB-EMS. Additionally, participants receive individualized nutritional counseling.
OTHERWB-EMS + HIIT
12-week supervised exercise program consisting of whole-body electromyostimulation (WB-EMS) and ergometer-based high-intensity interval training (HIIT). WB-EMS: Simulanteous stimulation of all major muscle groups with dedicated individual intensity. HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. 2 exercise sessions per week. Order of application: WB-EMS - HIIT. Additionally, participants receive individualized nutritional counseling.
OTHERHIIT + CST
12-week supervised exercise program consisting of ergometer-based high-intensity interval training (HIIT) and conventional low-volume strength training(CST). HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. CST: Conventional 1-set strength training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. 2 exercise sessions per week. Order of application: HIIT - CST. Additionally, participants receive individualized nutritional counseling.
OTHERCST + HIIT
12-week supervised exercise program consisting of conventional low-volume strength training(CST) and ergometer-based high-intensity interval training (HIIT). CST: Conventional 1-set strength training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. 2 exercise sessions per week. Order of application: CST - HIIT. Additionally, participants receive individualized nutritional counseling.
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking).
Intervention model description
Parallel Assignment parallel-group, randomized-controlled study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Body Mass Index \>25 * presence of at least 2 cardiometabolic risk factors
Exclusion criteria
* Healthy persons or patients under age * Overweight persons without any additional cardiometabolic risk factors * Pregnancy, Lactation * Psychological disorders, epilepsy, sever neurological disorders * Participation in other exercise- or nutrition studies within the last 6 months * acute cardiovascular disease * malignant disease * Electronic implants (defibrillator, pacemaker) * Persons in mental hospitals by order of authorities or jurisdiction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Metabolic Syndrome Z-Score (MetS-Z-Score). | 12 weeks | MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex. |
| Change in overall Physical Fitness Score (PFS) | 12 weeks | PFS is calculated from VO2max and 1 Repmax values of 5 major muscle Groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in HOMA-IR | 12 week | Insulin resistance will be estimated using homeostasis model assessment index (HOMA) |
| Change Inflammation status | 12 weeks | Inflammation will be assessed by measuring levels of inflammatory blood markers (CRP, inflammatory cytokines) |
| Change in Perceived stress | 12 weeks | Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ) |
| Change in Pain scores | 12 weeks | Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ) |
| Change Subjective work ability | 12 weeks | Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI) |
| Change in Health-related quality of life | 12 weeks | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire |
| Change in Body Composition | 12 weeks | Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA) |
Countries
Germany
Contacts
Primary ContactDejan Reljic, Dr.
Backup ContactYurdaguel Zopf, Prof.
Outcome results
None listed