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Breads Made With Triticum Heritage Varieties: Effect on Post-prandial Glycemia and Insulinemia

Breads Made With Triticum Heritage Varieties: Effect on Post-prandial Glycemia and Insulinemia

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03710200
Enrollment
13
Registered
2018-10-18
Start date
2018-10-12
Completion date
2018-11-15
Last updated
2019-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Modification

Brief summary

Wheat is one of the most important crop for humans and it represents a source of multiple nutrients, dietary fiber and bioactive compounds, especially if consumed as wholegrain. Several studies have suggested that Triticum heritage varieties could present a healthier and better nutritional profile than modern wheats, by providing more vitamins, minerals and nutraceutical compounds. Although the effect of ancient grain consumption have been partially investigated in both animal and human studies, the potential impact of Triticum heritage varieties compared to modern ones on post-prandial glucose metabolism is still unclear. Thus, the aim of the study was to evaluate the impact on post-prandial glycaemia and insulinemia of different types of breads formulated with flours derived from mix of heritage varieties belonging to the Triticum genus selected and cultivated in specific areas of Emilia Romagna region, compared to breads made with conventional/modern wheat flours.

Detailed description

Cereal grain based products constitute a major part of the daily diet, and wheat is the most important crop for humans representing a source of multiple nutrients, dietary fiber and bioactive compounds, especially if consumed as wholegrain. Depending on its physical and chemicals properties, such as structure of grains, granular size of semolina, quantity and quality of fiber and phytochemicals, amylose/amylopectin ratio, wheat may vehicle protective effects on human health. After the Green Revolution, most of wheat species grown are hybrids, which derive from ancient wheat over the last 100 to 150 years. The main results of this revolution were the development of modern varieties characterized by higher yield, a reduced susceptibility to disease and insects, an increase tolerance to environmental stresses, a homogeneous maturation and a better gluten quality, compared to ancient wheat. At the same time, a decrease in genetic variability as well as a gradual depletion of the nutritional and nutraceutical properties of the wheat occurred. However, over the last years, the increase of diet-related chronic disease led to the nutritional improvement of wheat for ameliorating its health potential. Nowadays, the higher value of whole grains than refined grains is recognized, while the nutritional effects of ancient versus modern grains is still controversial. Generally, ancient species are higher in vitamins, such as folate, niacin and vitamin B6, as well as in minerals such as calcium, iron, magnesium and phosphor compared to modern species, however evidence linked to their real health in vivo effects is still lacking. Therefore, the aim of the present study is to evaluate the nutritional profile of eight breads made with ancient (Triticum heritage varieties) or modern grains on the plasma response of glucose and insulin.

Interventions

OTHERBologna 00+S. cerevisiae yeast

Bologna 00 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL of water

OTHERBologna 1+S. cerevisiae yeast

Bologna 1 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERBio2+S. cerevisiae yeast

Bio2 bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERICARDA+S. cerevisiae yeast

Icarda bread made with yeast (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERBologna 1+sourdough

Bologna 1 bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERBio 2+sourdough

109g of Bio2 bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERICARDA+sourdough

Icarda bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water

OTHERGrossi+sourdough

Grossi bread made with sourdough (portion corresponding to 50g available carbohydrates) +500 mL water

Sponsors

University of Parma
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

-generally healthy

Exclusion criteria

* BMI≥30kg/m2 * have any health conditions (including anemia and metabolic conditions such as hypertension, dyslipidemia, impaired glucose intolerance or diabetes) * have celiac disease * currently taking any prescription medication for chronic diseases (including psychiatric) dietary supplements affecting the metabolism * Women who are pregnant or breastfeeding

Design outcomes

Primary

MeasureTime frameDescription
Post-prandial glycemic response2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)Post-prandial glycemic response (iAUC)

Secondary

MeasureTime frameDescription
Post-prandial response for insulin2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)Post-prandial response for insulin (iAUC)
Maximum peak for glucose and insulin2 hours (-10 and 0 -fasting-, 15, 30, 45, 60, 90, 120 minutes)maximum value of postprandial glucose and insulin response

Other

MeasureTime frameDescription
Satiety using a 100cm visual analog scale [ Time Frame: 2 hours ]2 hoursdifferences in subject-rated satiety using a 100cm visual analog scale
Gastrointestinal Symptoms using a questionnaire [ Time Frame: 2 hours ]2 hoursdifferences in subject-rated gastrointestinal symptom questionnaire

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026