Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases

Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases Among High-risk Populations in Lanxi, China

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03708952

Enrollment

25000

Registered

2018-10-17

Start date

2018-05-01

Completion date

2028-05-01

Last updated

2024-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Polyps

Keywords

Dietary factors, Precursor lesions of colorectal cancer, Lifestyle, Polyps, Cardiovascular Diseases

Brief summary

The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. This study is conducted in Jinhua, a city with a high prevalence of colorectal cancer in China, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

Detailed description

Investigations of lifestyle and dietary factors in relation to precursor lesions of colorectal cancer and cardiometabolic diseases are limited in China. The investigators aim to collect the basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors and so on, to assess the associations between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases. This large cohort - the Lanxi Pre-colorectal Cancer Cohort (LP3C) also included several subcohorts consisting of patients with CVD, diabetes, hypertension, metabolic syndrome, obese/overweight or fatty liver disease. Results from this study will be valuable for colorectal cancer and cardiometabolic disease prevention in China.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 74 Years

Healthy volunteers

Yes

Inclusion criteria

* Subject aged ≥45 and ≤74 years old * Subject has complete data on diet and follow-up time

Exclusion criteria

* Colorectal cancer * Severe intestines problems

Design outcomes

Primary

Measure	Time frame	Description
Numbers of participants with polyps	From entry into the study (baseline:2018-2022) until 2028	All polyps

Secondary

Measure	Time frame	Description
Numbers of participants with different subtypes of polyps	From entry into the study (baseline:2018-2022) until 2028	Subtypes of polyps, including serrated polyps, hyperplastic polyps, sessile serrated polyps/adenoma
Numbers of participants with cardiometabolic diseases	From entry into the study (baseline:2018-2022) until 2028	Cardiometabolic diseases including cardiovascular disease, diabetes, and hypertension

Other

Measure	Time frame	Description
Numbers of participants died	From entry into the study (baseline:2018-2022) until 2028	All-cause and cause-specific mortality outcomes

Countries

China

Outcome results