Long Term Effects and of a Pulmonary Rehabilitation Maintenance Program

Long Term Effects and of a Pulmonary Rehabilitation Maintenance Program in Patients With a Chronic Respiratory Disease: Time Course and Determinants

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03704935

Acronym

LTAir+R

Enrollment

1000

Registered

2018-10-15

Start date

2018-10-10

Completion date

2019-12-30

Last updated

2020-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Respiratory Disease

Keywords

Pulmonary rehabilitation, Maintenance program, Cohort, Microenvironment, Long-term benefits

Brief summary

Chronic respiratory diseases are characterized by a progressive and long term deline. Pulmonary rehabilitation (exercise training and therapeutic education) can improve several disease outcomes like dyspnea, exercise tolerance and health-related quality of life. After an inpatient PR program, maintenance program can stabilize the disease outcomes. However, maintenance program are heterogeneous and long term benefits (\>36 month) have been observed in only one study, which is not feasible in France. A realistic maintenance program as proposed by the French Air+R network (http://airplusr.com/wordpress/) has only demonstrated benefits after 12 month. In addition, the time course of patients may be heterogeneous, with differens clusters that could be influenced by the clinical, functional and systemic determinants. In particular, the cellular muscle microenvironment could be deleterious for the muscle function in patients, caused by a spill-over of inflammatory pulmonary molecules in the systemic milieu.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 100 Years

Healthy volunteers

Inclusion criteria

Patients with a chronic respiratory disease (COPD, Asthma, bronchiectasis , Fibrosis, Sleep Apnea, …) undergoing pulmonary rehabilitation (maintenance or inpatient)

Exclusion criteria

Contraindication to exercise training

Design outcomes

Primary

Measure	Time frame	Description
6 minutes walking distance	10 years	6 minutes walking distance

Secondary

Measure	Time frame	Description
health-related quality of life	10 years	health-related quality of life : VQ-11 questionnaire
Forced expiratory volume in 1 seconde	10 years	Forced expiratory volume in 1 seconde : FEV1
BODE index	10 years	BODE index
death	10 years	death

Countries

France

Outcome results