Old Age
Conditions
Keywords
Spinal anesthesia in old age
Brief summary
As people age, the incidence of prostate hyperplasia increases. So patients under Transurethral Resection of Prostate(TURP) or Holmium Laser Ennucleation of Prostate(HoLEP) are mostly ole age people. Most old age patient has several underlying disease. So patients can develop high mortality and morbidity. Most surgeries for Prostate Resection are taken under Spinal anesthesia. Adequate block level for Prostate Resection is T10. But sometimes, old age patients can develop severe complication after spinal anesthesia. So we started this study to know the adequate drug concentration for Spinal anesthesia taken for Prostate Resection surgery.
Detailed description
As people age, the incidence of prostate hyperplasia increases. So patients under Transurethral Resection of Prostate(TURP) or Holmium Laser Ennucleation of Prostate(HoLEP) are mostly ole age people. Most old age patient has several underlying disease. So patients can develop high mortality and morbidity. Most surgeries for Prostate Resection are taken under Spinal anesthesia. Adequate block level for Prostate Resection is T10. But sometimes, old age patients can develop severe hypotension and vital unstability due to unintentional high sensory and motor blocks. These complications are due to the decreased cerebrospinal fluid volume with increase of age. So we started this study to know the adequate drug concentration for Spinal anesthesia taken for Prostate Resection surgery.
Interventions
DRUGBupivacaine
bupivacaine dose
Sponsors
Hallym University Kangnam Sacred Heart Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
65 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients scheduled for TURP & HoLEP under spinal anesthesia * Male between 65 and 100 * The American Society of Anesthesiologists physical status class 1 or 2
Exclusion criteria
* Patients with coagulopathy * Patients with infectious disease * Patients with a drug allergy * Patients under 50kg or over 100kg * In case of switching to general anesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ED50 and ED95 of intrathecal hyperbaric bupivacaine with fentanyl for transurethral prostatectomy in elderly patients | 2years | ED50(50% Effective dose) and ED95(95% Effective dose) of intrathecal hyperbaric bupivacaine with fentanyl for transurethral prostatectomy in elderly patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| comparison of incidence of complications(hypotension, nausea/vomiting and shivering) during perioperative period | 2years | comparison of incidence of complications(hypotension, nausea/vomiting and shivering) during perioperative period |
Countries
South Korea
Outcome results
None listed