Postoperative Cognitive Dysfunction
Conditions
Keywords
Postoperative Cognitive Dysfunction, Leukocyte Telomere Length
Brief summary
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
Interventions
DIAGNOSTIC_TESTNeuropsychology test
We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.
Sponsors
Xuzhou Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Non-cardiac surgery patients; * Age is greater than or equal to 65 years old; * Han Nationality, mother tongue is chinese; ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; ⑤The Geriatric Depression Scale (GDS) grade 1 or 2; ⑥The important function without serious heart, brain, liver, kidney, lung and other organs; * The ASA class I or II; * The people signed informed consent.
Exclusion criteria
* The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery; * Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the neuropsychological test to measure cognitive function | 1 day before surgery(baseline) |
| Mini-Mental score examination [MMSE] used for screening of dementia | 1 day before surgery(baseline) |
| the leukocyte telomere length | on the surgery day |
Countries
China
Contacts
Primary ContactJunli Cao
Backup ContactYuan Han
Outcome results
None listed