Hypoglycemia
Conditions
Brief summary
A single supraphysiological course of exogenous corticosteroids is recommended between 24-34 weeks' gestation to minimize the adverse sequelae associated with prematurity. The 24-hour profile of endogenous corticosteroids normally follows a diurnal rhythm with the highest serum level occurs between 5am-11am and nadir over 12 hours.
Detailed description
A retrospective study from January 2010 to December 2017. Eligible for analysis are: singleton pregnancies between 24 - 34 weeks' gestation who were given a single course of intramuscular betamethasone. Single course comprised of two separate doses of 12 mg given 24 hours apart. Each woman was allocated into one of the four pre-defined groups based on the time the intramuscular betamethasone was administered; Group 1 (5am-11am), group 2 (11am-5pm), group 3 (5pm-11pm) and group 4 (11pm-5am). The investigators hypothesized that exogenous corticosteroids given during the nadir state of endogenous corticosteroids activity could alter maternal and fetal glucose homeostasis.
Interventions
DRUGBetamethasone
Corticosteroids
Sponsors
Rambam Health Care Campus
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
• women between 24 - 34 weeks' gestation who were admitted and given a single course of intramuscular betamethasone for threatened preterm labor in our institution
Exclusion criteria
* higher order multiple pregnancies * women who were given more than one course of betamethasone during the course of the current pregnancy * known major congenital anomalies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of neonatal hypoglycemia | 7 years | Incidence of neonatal hypoglycemia, glucose ˂ 40 mg/dL at any time |
Countries
Israel
Contacts
Primary ContactYaniv Zipori, M.D
Outcome results
None listed