Effect of Anesthetic Agents on Optic Nerve Sheath Diameter

Effect of Anesthetic Agents (Propofol, Sevoflurane) on Optic Nerve Sheath Diameter(ONSD) in Patients Undergoing Robot-assisted Laparoscopic Gynecology Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03701529

Enrollment

Registered

2018-10-10

Start date

2018-10-15

Completion date

2019-09-16

Last updated

2020-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine Cancer, Uterus Myoma

Brief summary

The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.

Detailed description

Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases. Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.

Interventions

DRUGSevoflurane

1.5-2.5 vol % sevoflurane is used for maintenance of anesthesia.

DRUGPropofol

2-5 mcg/ml of propofol is used for maintenance of anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy

Exclusion criteria

* history of brain hemorrhage or brain infarction * liver disease or end stage renal disease * glaucoma or any signs of increased intraocular pressure * combined wtih other types of operation * patient refusal * weight less than 40 kg or over 100 kg

Design outcomes

Primary

Measure	Time frame	Description
difference of optic nerve sheath diameter	During the operation.	optic nerve sheath diameter is measured using sonographic probe. (10 minutes after induction of anesthesia/ 5 minutes after pneumoperitoneum and trendelenburg position / 20 minutes after pneumoperitoneum and trendelenburg position / 40 minutes after pneumoperitoneum and trendelenburg position / skin closure)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026