Appetite, Ghrelin, GLP - 1, Gut Hormones, Obesity, PYY, VAS of Hunger, VAS of Satiety
Conditions
Brief summary
Obesity can occur due to an imbalance of energy. This energy balance is greatly influenced by hunger and satiety. Obese person cannot resist hunger, while non obese can control hunger. Gut hormones, such as PYY and ghrelin, are associated with appetite and satiety control. This study's objective is to compare the effect of breakfast with balance composition on gut hormones, glucose and ad libitum intake four hours after breakfast between obese and non obese.. The research methodology was used a clinical trial with 18 obese women and 22 non obese women participants. Subjects were given a balance breakfast (protein 12,4%, carbohydrate 68,2%, fat 22,6%). Gut hormones (PYY, Ghrelin, GLP -1) level , Glucose level and satiety level were measured at 0, 15, 60, 120, and 180 minutes after breakfast. Ad libitum meal was given four hours after breakfast and measured after.
Interventions
BEHAVIORALDiet with balance composition to know the effect of a meal to gut hormones in obese and non obese women
Sponsors
SEAMEO Regional Centre for Food and Nutrition
Dr Cipto Mangunkusumo General Hospital
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 25 - 30 (for obese am) * BMI 18,5 - 23 (for NON- obese am) * with stable body weight within the last 6 months (body weight change less than 4 kg) * normal blood glucose level.
Exclusion criteria
* Patients who never had breakfast * patients in weight loss program * patients consuming lipid-absorption inhibitor or appetite-suppressing drugs * patients that have had gastrointestinal tract resection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ghrelin levels at 0 minute | baseline | analyzed by ELISA, directly taken after having the breakfast with balance composition in both of the study arm. |
| Ghrelin levels at 15 minute | 15 minutes | analyzed by ELISA, taken 15 minutes after having the breakfast with balance composition in both of the study arm. |
| Ghrelin levels at 60 minute | 60 minutes | analyzed by ELISA, taken 60 minutes after having the breakfast with balance composition in both of the study arm. |
| Ghrelin levels at 120 minute | 120 minutes | analyzed by ELISA, taken 120 minutes after having the breakfast with balance composition in both of the study arm |
| Ghrelin levels at 180 minute | 180 minutes | analyzed by ELISA, taken 180 minutes after having the breakfast with balance composition in both of the study arm |
| PYY levels at 0 minute | baseline | analyzed by Radioimmunoassay, directly taken after having the breakfast with balance composition in both of the study arm |
| PYY levels at 15 minute | 15 minutes | analyzed by Radioimmunoassay, taken 15 minutes after having the breakfast with balance composition in both of the study arm |
| PYY levels at 60 minute | 60 minutes | analyzed by Radioimmunoassay, taken 60 minutes after having the breakfast with balance composition in both of the study arm |
| PYY levels at 120 minute | 120 minutes | analyzed by Radioimmunoassay, taken 120 minutes after having the breakfast with balance composition in both of the study arm |
| PYY levels at 180 minute | 180 minutes | analyzed by Radioimmunoassay, taken 180 minutes after having the breakfast with balance composition in both of the study arm |
| GLP-1 levels at 0 minute | baseline | analyzed by ELISA, directly taken after having the breakfast with balance composition in both of the study arm |
| GLP-1 levels at 15 minute | 15 minutes | analyzed by ELISA, taken 15 minutes after having the breakfast with balance composition in both of the study arm |
| GLP-1 levels at 60 minute | 60 minutes | analyzed by ELISA, taken 60 minutes after having the breakfast with balance composition in both of the study arm |
| GLP-1 levels at 120 minute | 120 minutes | analyzed by ELISA, taken 120 minutes after having the breakfast with balance composition in both of the study arm |
| GLP-1 levels at 180 minute | 180 minutes | analyzed by ELISA, taken 180 minutes after having the breakfast with balance composition in both of the study arm |
| Glucose levels at 0 minute | baseline | analyzed by standard random glucose level from venous blood, directly taken after having the breakfast with balanced composition in both of the study arm |
| Glucose levels at 15 minute | 15 minutes | analyzed by standard random glucose level from venous blood, taken 15 minutes after having the breakfast with balanced composition in both of the study arm |
| Glucose levels at 60 minute | 60 minutes | analyzed by standard random glucose level from venous blood, taken 60 minutes after having the breakfast with balanced composition in both of the study arm |
| Glucose levels at 120 minute | 120 minutes | analyzed by standard random glucose level from venous blood, taken 120 minutes after having the breakfast with balanced composition in both of the study arm |
| Glucose levels at 180 minute | 180 minutes | analyzed by standard random glucose level from venous blood, taken 180 minutes after having the breakfast with balanced composition in both of the study arm |
| Ad Libitum intake | 4 hours | Mean Ad Libitum intake (calories) in subjects four hours after breakfast with balance composition in both of the study arm |
| VAS for hunger at 0 minutes | baseline | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), directly taken after having the breakfast with balance composition in both of the study arm |
| VAS for hunger at 15 minutes | 15 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 15 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for hunger at 60 minutes | 60 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 60 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for hunger at 120 minutes | 120 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 120 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for hunger at 180 minutes | 180 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 180 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for satiety at 0 minutes | baseline | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), directly taken after having the breakfast with balance composition in both of the study arm |
| VAS for satiety at 15 minutes | 15 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 15 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for satiety at 60 minutes | 60 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 60 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for satiety at 120 minutes | 120 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 120 minutes after having the breakfast with balance composition in both of the study arm |
| VAS for satiety at 180 minutes | 180 minutes | Visual Analog Scale, a scale in the form of an empty straight line with no values but only several level point (ex: if the line is 10cm, then each cm represent 1 level). Extreme choices are both ends of the straight line. The minimum value is at the left end and the maximum value is at the right end. The subject must make a choice between the two ends of the line by giving an X mark (ex : if the subject feels less hunger, then the subject should mark X at the second point from far left), taken 180 minutes after having the breakfast with balance composition in both of the study arm |
Countries
Indonesia
Outcome results
None listed