Obesity, Abdominal
Conditions
Keywords
Abdominal Fat, Visceral Adipose Tissue, Subcutaneous Adipose Tissue, Exercise, Intervention
Brief summary
Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.
Interventions
OTHERResistance Training
High-intensity Resistance Training Group
OTHERAerobic Training
Aerobic Interval Training Group
Sponsors
Washington University School of Medicine
Southern Illinois University Edwardsville
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* 30 - 39.9 kg/m2 BMI * White/Caucasian * Female * Sedentary
Exclusion criteria
* Known cardiovascular, pulmonary, metabolic disease * Pregnant females * Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos) * Diabetic * Hypertension * Cigarette smoking * MRI related contraindications (metal, no removable devices, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Visceral Abdominal Tissue (VAT) | 2 assessment periods: at baseline and week 4 | Changes in VAT will be measured using Magnetic Resonance Imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Muscular Strength | 2 assessment periods: at baseline and week 4 | Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press |
| Changes in Cardiorespiratory Function | 2 assessment periods: at baseline and week 4 | Changes in cardiorespiratory will measured on a treadmill with a metabolic cart |
| Changes in fat mass (kg) | 2 assessment periods: at baseline and week 4 | Changes in fat mass will be measured using dual-energy x-ray absorptiometry |
| Changes in relative body fat (%BF) | 2 assessment periods: at baseline and week 4 | Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry |
| Changes in relative lean body mass (kg) | 2 assessment periods: at baseline and week 4 | Changes in lean body mass will be measured using dual-energy x-ray absorptiometry |
| Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL) | 2 assessment periods: at baseline and week 4 | Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis |
| Changes in Subcutaneous Abdominal Tissue (SAT) | 2 assessment periods: at baseline and week 4 | Changes in SAT will be measured using Magnetic Resonance Imaging |
| Changes in concentration of Fibrinogen | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
| Changes in concentration of C-reactive protein (CRP) | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
| Changes in concentration of IL-6 | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
| Changes in concentration of IL-10 | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
| Changes in concentration of TNF-alpha | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
| Changes in concentration of Troponin | 2 assessment periods: at baseline and week 4 | Will be performed using a Luminex MAGPIX System with xPONENT 4.2 |
Countries
United States
Outcome results
None listed