Effect of Tio2 Nanoparticles on Candida Aggregation
Conditions
Brief summary
Cross over design the investigator divide participants to two groups group (A) will receive rapid heat cured denture base material and group (b) will receive the acrylic denture modified by titanium dioxide nanoparticles and after washout period alternatively group (a) will receive the acrylic denture modified by titanium dioxide nanoparticles AND group (b) will receive rapid heat cured denture base material the investigator will take swaps from dentures to count the candida species
Interventions
patients will receive titanium dioxide denture (made from acrylic resin with titanium dioxide nanoparticles ) for 1 month in the initial phase then in the second phase after one month they will receive( rapid heat cured acrylic resin)denture according to the principle of crossover des
Sponsors
Ali ibrahim mahmoud shamardal
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Completely edentulous maxillary arch and partially dentate mandibular arch with adequate interarch space. * The edentulous ridges should be covered by firm healthy mucosa. * Angle class I maxillomandibular relation. * Healthy and cooperative patient
Exclusion criteria
* Patients with bad habits as severe clenching or bruxism, drug or alcohol addiction, moderate or heavy smoking (greater than 10 cigarettes per day). * Previous history of radiotherapy or chemotherapy. * Any skeletal problem dictates surgical intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mycological investigation | 6 months | Count of candida on the fitting surface of denture by (CFU) unit |
Outcome results
None listed