Early Detection of Head and Neck Superficial Squamous Cell Carcinoma in Patients With Esophagus Squamous Cell Carcinoma

Early Detection of Oropharyngeal and Hypopharyngeal Superficial Squamous Cell Carcinoma in Patients With Esophagus Squamous Cell Carcinoma by White Light Imaging and Optical Enhancement(OE)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03700398

Enrollment

214

Registered

2018-10-09

Start date

2017-10-01

Completion date

2019-02-01

Last updated

2018-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optical Enhancement Endoscopy

Brief summary

the investigators randomly divide the eligible objects into two groups:1. objects in this group will first receive OE endoscopy observation and subsequent white light imaging(WLI) observation during oropharynx and hypopharynx; 2. objects in this group will first receive WLI observation and subsequent OE observation during oropharynx and hypopharynx. Then, the investigators will compare the detect rate of oropharyngeal and hypopharyngeal superficial squamous cell carcinoma of two groups to find if OE endoscopy can improve the detect rate of oropharyngeal and hypopharyngeal superficial squamous cell carcinoma in esophageal cancer patients.

Interventions

DEVICEfirst OE

optical enhancement(OE)，a kind of electron straining endoscopy

DEVICEfirst WLI

the routine in the clinical practice

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* order than 18 years old * Previous or current histopathological pathology confirmed the presence of esophageal squamous cell carcinoma

Exclusion criteria

* Previously confirmed pharynx/oropharyngeal squamous cell carcinoma * Advanced pharynx/hypopharyngeal squamous cell carcinoma * Pregnant women and lactating women * pharyngeal or esophageal stenosis, esophageal varices, or active digestive tract hemorrhage influence the observation or fail to obtain pathological diagnosis * Previous chemotherapy or radiation therapy affected observation * Not completed gastroscopy or refused to take biopsy for various reasons * Mental illnesses such as anxiety and depression affect the endoscopic observation * Severe systemic disease, can not tolerate gastroscopy * Refusal to sign informed consent books

Design outcomes

Primary

Measure	Time frame	Description
detect rate	12 months	the detect rate of oropharyngeal and hypopharyngeal superficial squamous cell carcinoma

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026