Robotic Esophagectomy
Conditions
Brief summary
The aim of this study was to determine whether changes in serum levels of syndecan-1 before and after surgery, which is an index related to injury of the endothelial glycocalyx layer, are associated with postoperative short-term complications and mortality in patients undergoing robotic esophagectomy.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. patients 20 years or older who undergo robotic esophagectomy
Exclusion criteria
1. Emergency surgery 2. If the subject includes a person who can not read the written consent (eg, illiterate, foreigner, etc.) 3. Chronic kidney disease (eGFR \<30 mL / min / 1.73 m2) 4. Pregnant and lactating women 5. Use of oral anticoagulants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| base blood concentration of syndecan-1 | within 1 hour before surgery | preoperative baseline serum levels of syndecan-1 |
| blood concentration of syndecan-1 at the end of the surgery | within 5 minutes after the end of surgery (when thd surgical drape is removed) | blood concentration of syndecan-1 at the end of the surgery |
| blood concentration of syndecan-1 at 24 hours after surgery | 24 hours after the end of surgery | blood concentration of syndecan-1 at 24 hours after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| initial ventilatory support greater than 48 hours (STS GTSD 2.41 #3520) | within 30days after end of surgery | Indicate if the patient initially was ventilated greater than 48 hours in the postoperative period. If the patient is reintubated, select the postoperative event Respiratory Failure and do not select this element even if the reintubation ventilator support is \> 48 hours. Ventilator support ends with the removal of the endotracheal tube or if the patient has a tracheostomy tube, until no longer ventilator dependent. |
| pneumonia (STS GTSD 2.41 #3460) | within 30days after end of surgery | Indicate if the patient experienced pneumonia in the postoperative period. Pneumonia is defined as meeting three of five characteristics: fever (\> 100.4 F or 38 C), leukocytosis, CXR with infiltrate, positive culture from sputum, or treatment with antibiotics. |
| Unanticipated Post-Operative Invasive Procedure (STS GTSD 2.41 #3330) | during this 1 day hospital visit. | Indicate if the patient had an unplanned invasive procedure after surgery. Examples includes return to the operating room for a redo surgical procedure, a percutaneous procedure performed at bedside or in the radiology suite, a tracheostomy, and wound opening at bedside. Exclusions: postoperative toilet bronchoscopy, central venous access, arterial line placement, foley catheter placement. |
| mortality(Status 30 Days after Surgery, STS GTSD 2.41 #3950) | 30days post-surgery | Indicate whether the patient was alive or dead at 30 days post-surgery (whether in the hospital or not). time frame: 30days post-surgery |
| Acute kidney injury | within 48 h after end of surgery | defined as an absolute increase in serum creatinine level C0.3 mg/dL, a 50% (1.5-fold) increase in serum creatinine level from baseline, or a reduction in urine output (documented oliguria\< 0.5 mL/kg/h for 6h) |
| renal failure(STS GTSD 2.41 #3810) | within 30days after end of surgery | Indicate whether the patient had acute renal failure or worsening renal function resulting in any of the following: 1. New requirement for dialysis post-operatively 2. Increase in serum creatinine level 3.0 x greater than baseline 3. serum creatinine level ≥4 mg/dL , with an acute rise of at least 0.5 mg/dl |
| Anastomotic leak following esophageal surgery(STS GTSD 2.41 #3350) | within 30days after end of surgery | Indicate if the patient had an anastomotic leak following esophageal surgery. |
| Respiratory Failure(STS GTSD 2.41 #3480) | within 30days after end of surgery | Indicate whether the patient experienced respiratory failure in the postoperative period requiring mechanical ventilation and/or reintubation. |
Countries
South Korea
Outcome results
None listed