Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03697590

Enrollment

Registered

2018-10-05

Start date

2017-06-01

Completion date

2017-12-20

Last updated

2018-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratosis, Actinic

Brief summary

Guidelines for photodynamic therapy (PDT) of actinic keratosis recommend pretreatment with curettage. The impact of curettage on the treatment effect is, however, not known. The present study aimed to evaluate whether daylight-PDT without curettage would reduce treatment effect compared to daylight-PDT with curettage.

Interventions

DRUGNo curettage

Standard PDT without curettage

DRUGCurettage

Standard PDT

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Multiple actinic keratosis on the forehead or scalp

Exclusion criteria

* Known allergy to methyl aminolevulinate * Porphyria * Pregnancy * Lactation

Design outcomes

Primary

Measure	Time frame	Description
Complete lesion response rate	Treatment efficacy was evaluated 3 months after PDT	Complete lesion response rate, was defined as the number of completely responding lesions divided by the total number of treated lesion in each field. Complete lesion response was defined as complete disappearance of the lesion both by palpation and visually.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026