Atherosclerosis, Metabolic Syndrome
Conditions
Brief summary
Reduced ambulatory activity has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of daily ambulation on response to a HFTT after an acute aerobic exercise bout.
Interventions
BEHAVIORALVery Low Steps
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Very Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
BEHAVIORALLow Steps
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
BEHAVIORALModerate Steps
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Moderate Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
Sponsors
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Subjects will complete three experimental conditions which include 2 days of reduced step count (2,500, 5,000, and 7,500 steps/day) with 1-hour of exercise at 65% VO2max.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Exclusion criteria
* Cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.) * Respiratory problems * Musculoskeletal problems that prevent prolonged sitting or exercise * Obesity * Susceptibility to fainting * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6-Hour Plasma Triglyceride Area Under the Curve | 6-hours | Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6-Hour Plasma Insulin Area Under the Curve | 6-hours | Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test |
| 6-Hour Plasma Glucose Area Under the Curve | 6-hours | Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test. |
Countries
United States
Outcome results
None listed