Effect of Magnesium Sulphate on Analgesia Following Knee Arthroplasty

The Effect of Magnesium Sulfate Added to Levobupivacaine in Continous Femoral Block on Analgesic Requirements Following Total Knee Arthroplasty

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03695640

Enrollment

Registered

2018-10-04

Start date

2018-11-01

Completion date

2018-12-15

Last updated

2018-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Arthroplasty, Total, Postoperative Pain

Keywords

total knee arthroplasty, postoperative pain, continuous femoral nerve block, magnesium sulphate

Brief summary

This study is designed to investigate the effect of magnesium sulfate added to levobupivacaine in continuous femoral nerve block following total knee arthroplasty.

Detailed description

Pain after knee arthroplasty is a serious concern. This study was designed to investigate the effect of magnesium sulfate added to levobupivacaine in continuous femoral nerve block on analgesic requirements following total knee arthroplasty.

Interventions

DRUGMagnesium Sulfate

Addition of magnesium sulfate as an adjuvant to levobupivacaine

PROCEDUREcontinuous femoral nerve block

continuous nerve block with levobupivacaine for treatment postoperative pain

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Intervention model description

randomized, controlled, prospective

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* scheduled for elective unilateral primary total knee arthroplasty

Exclusion criteria

* Patient refusal to enroll in the study * Patient refusal of neuraxial anesthesia * Existence of contraindications for neuraxial anesthesia * Known history of allergy to any of the study drugs

Design outcomes

Primary

Measure	Time frame	Description
Visual Analogue Score	T0:(Baseline) Postoperative 1st hour, T1: Change in 2nd, T2: Change in 4th, T3: Change in 6th, T4: Change in 12th, T5: Change in 24th, T6: Change in 36th, T7: Change in 48th, T8: Change in 72nd hours	measurement of postoperative pain using Visual Analogue Score. Minimum: 0 Maximum: 10. Higher values represent more pain, hence lower values are better

Secondary

Measure	Time frame	Description
Analgesic consumption	T0:(Baseline) Postoperative 1st hour, T1: Change in 2nd, T2: Change in 4th, T3: Change in 6th, T4: Change in 12th, T5: Change in 24th, T6: Change in 36th, T7: Change in 48th, T8: Change in 72nd hours	Consumption of local anesthetic in patient controlled analgesia

Countries

Turkey (Türkiye)

Contacts

Primary ContactBaturay K Kazbek, MD

bkkazbek@gmail.com+903122044000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026