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Physical Activity, Dietary Intake and Bone Status in 6-12 Years Children

Effect of Nutrition and Physical Activity on Bone Status in 6-12 Years Children

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03695328
Acronym
Nutri-Bone
Enrollment
210
Registered
2018-10-04
Start date
2015-09-15
Completion date
2018-05-15
Last updated
2018-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Status

Brief summary

Peak bone mass acquisition through childhood and adolescence has been associated with lower risk of osteopenia and osteoporosis in the elderly. The main factors that influence bone mass are the non-modifiable, such as genetics, ethnicity and sex, and the modifiable ones which are nutrition and physical activity or exercise. In the literature are references that demonstrates positive effects of high physical activity, adequate intakes of macro- and micronutrients on bone mass both in adults and in children. Bone mineralization is more adaptive in childrens' growing bones and this is an opportunity for stronger effects by mechanical stimuli during physical activity. The presence of a diet complete of nutrient intakes seems to strengthen the effects of mechanical loads on bone growth and mineralization. The present trial aimed to evaluate the effects of physical activity and nutrition intakes on bone mass in pre-pubertal children.

Detailed description

The sample of this study was healthy pre-pubertal boys and girls (N=210) who had training age 0-1 years. Data collection included anthropometric measurements, blood sampling, body composition, bone measurements and physical performance measurements. Nutritional intake was recorded for seven consecutive days in order to evaluate nutrient intakes using an appropriate software and habitual physical activity was measured for the same days using accelerometers. Pubertal stage determined by Tanner scale. All measurements were made only once at the beginning of school year.

Interventions

BEHAVIORALphysical activity level
BEHAVIORALDietary Intake

Sponsors

Democritus University of Thrace
Lead SponsorOTHER

Study design

Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
Yes

Inclusion criteria

* were 6-12 years and pre-pubertal * were healthy and had no prior bone fractures or related surgical operation * their body fat was \<30%, e) had no history of growth irregularities * were not receiving agents or drugs that affect bone tissue (e.g. Gonadotropin-Releasing Hormone (GnRH) agonists, antiresorptive, bisphosphonates, etc.)

Exclusion criteria

* had prior bone fractures or related surgical operation * their body fat was \>30% * had history of growth irregularities * were receiving agents or drugs that affect bone tissue (e.g. GnRH agonists, antiresorptive, bisphosphonates, etc.)

Design outcomes

Primary

MeasureTime frameDescription
Flexibility1 day (Once)Sit and reach test
Hips bone mineral content1 day (Once)Measured by Dual-X-ray Absoroptiometry
Body composition1 day (Once)Measured by Dual-X-ray Absoroptiometry and skinfolds
Muscular strength1 day (Once)Handgrip strength
Cardiovascular endurance1 day (Once)20m shuttle run test
Whole body bone mineral density1 day (Once)Measured by Dual-X-ray Absoroptiometry
Lumbar spine bone mineral density1 day (Once)Measured by Dual-X-ray Absoroptiometry
Hips bone mineral density1 day (Once)Measured by Dual-X-ray Absoroptiometry
Whole body mineral content1 day (Once)Measured by Dual-X-ray Absoroptiometry
Lumbar spine bone mineral content1 day (Once)Measured by Dual-X-ray Absoroptiometry

Secondary

MeasureTime frameDescription
Serum vitamin D1 day (Once)Measured in blood smaples
Serum calcium1 day (Once)Measured in blood smaples
Pubertal Stage1 day (Once)Evaluated with Tanner Stage protocol
Sclerostin1 day (Once)Measured in blood samples with an appropriate kit

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026