Chronic Kidney Diseases
Conditions
Brief summary
Parathyroid hormone (PTH) may play an important role in the down-regulation of CYP3A4 expression induced by Chronic kidney diseases (CKD). In the study of molecular mechanism, the research group found that the expression of CYP3A2 metabolic enzyme in rat liver decreased in the state of CKD.And PTH may down-regulate the expression of CYP3A4 metabolic enzyme by inhibiting the expression of Nuclear factor- Kilobuse (NF-kB) p65 subunit
Interventions
DRUGNifedipine controlled released tablets
lower blood pressure
Sponsors
The Third Xiangya Hospital of Central South University
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chinese male or female subjects with an age of 18 or older were included; * The clinical physician diagnosed CKD with hypertension; * The physician decided that nifedipine controlled release tablets should be given. * Subjects agree to the study protocol, clinical and follow-up time, and sign the informed consent after the approval of the ethics committee; * Subjects will be able to communicate well with the investigator and will be able to complete the study as required.
Exclusion criteria
* Patients with CKD requiring dialysis treatment; * Other clinical reasons that may be considered inappropriate for inclusion by clinicians.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the concentration of nifedipine | at 5-7days | the concentration of nifedipine |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24-hour ambulatory blood pressure | at 1 day and 7day | mean blood pressure |
Countries
China
Contacts
Primary ContactYang Guoping, doctor
Outcome results
None listed