Acute Respiratory Failure, Bradyarrhythmia, Dyspnea
Conditions
Brief summary
FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature. In this study, the investigator would like to evaluate the effectiveness and safety of NTUH experience in FFR prospectively. First, the investigator will record any intracoronary (IC) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. Second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. Finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-BNP), and high sensitivity C- reactive protein (hsCRP) will be checked and determined their relationships with the maximum dosage of IC adenosine.
Detailed description
FFR has been introduced for the determination of physiological ischemia in the myocardium for many years. Nowadays, FFR-guided PCI is highly recommended for the assessment of physiologic ischemia in intermediate coronary lesions. FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature. In this study, the investigator would like to evaluate the effectiveness and safety of NTUH experience in FFR prospectively. First, the investigator will record any intracoronary (IC) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. Second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. Finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-BNP), and high sensitivity C- reactive protein (hsCRP) will be checked and determined their relationships with the maximum dosage of IC adenosine.
Interventions
None listed
Sponsors
National Taiwan University Hospital Hsin-Chu Branch
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Eligible for FFR examination
Exclusion criteria
* Hypersensitivity to adenosine * Severe valvular aortic stenosis * Resting heart rate less than 50 beats per minute
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adenosine related adverse event | 24 hours | Including 1. Bradyarrhythmia including sinus pause and transient AV block 2. Acute respiratory failure define by respiratory distress which need mechanical ventilator support |
| Major adverse cardiac event (MACE) | 2 year | MACE including target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The relationship between left ventricular diastolic pressure and maximum dosage of IC adenosine | 1 hour | Determine the correlation of left ventricular diastolic pressure and peak dosage of IC adenosine with FFR protocol in NTUH system |
Other
| Measure | Time frame | Description |
|---|---|---|
| The relationship between pro-BNP,hs-CRP and maximum dosage of IC adenosine | 1 day | Determine the correlation of pro-BNP,,hs-CRP and peak dosage of IC adenosine with FFR protocol in NTUH system |
Countries
Taiwan
Contacts
Primary ContactChien-Boon Jong, MD
Outcome results
None listed