Tobacco Use Disorder
Conditions
Keywords
Transcranial Direct Current Stimulation
Brief summary
This study aims to detect how transcranial direct current stimulation (tDCS) affects smokers' inhibitory control, craving and consumption of tobacco goods.
Detailed description
Participating smokers are to receive anodal transcranial direct current stimulation of the right dorsolateral prefrontal cortex (rDLPFC) for 20 minutes on five consecutive days. Neuropsychological tests on inhibitory control and interviews on smoking habits and craving will be applied before and after the first stimulation as well as after the fifth stimulation. After a follow-up period of three days, smoking behaviour will be assessed in a telephone interview. Changes in inhibitory control and smoking behaviour will be compared between an active and a sham stimulation group.This way the effects of transcranial direct current stimulation on tobacco use disorder are to be clarified.
Interventions
DEVICEtDCS
The participants will receive anodal tDCS (transcranial direct current stimulation) of the right dorsolateral prefrontal cortex for 20 minutes on five consecutive days.
DEVICESham tDCS
The participants will receive sham tDCS (transcranial direct current stimulation) of the dorsolateral prefrontal cortex for 20 minutes on five consecutive days.
Sponsors
Central Institute of Mental Health, Mannheim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
Participants will be blinded as to their assigned study arm.
Intervention model description
Half of the participants will receive transcranial direct current stimulation, while the others will receive sham stimulation.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* tobacco use disorder * normal or correctable eyesight * sufficient ability to communicate with the investigators, to answer questions in oral and written form * fully informed consent * written informed consent
Exclusion criteria
* withdrawal of the declaration of consent *
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduced number of cigarettes smoked | First assessment on Day 1, second on Day 8 | Smoking habits will be assessed via interview at the beginning of the study and after a follow-up period of three days. Number of cigarettes smoked will be compared longitudinally and between groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduced Carving | First assessment on Day 1, second on Day 5, third on Day 8 | Craving will be assessed using visual analog scales on the first and fifth day of the study as well as in the follow-up interview. Ratings will be compared longitudinally and between groups.. |
| Increased inhibitory control | First and second testing on Day 1, third testing on Day 5 | Inhibitory control will be assessed in neuropsychological tests (Go / No-Go, Stop-Signal Task) before and after the first stimulation session and after the fifth session. Results will be compared longitudinally and between groups. |
Countries
Germany
Outcome results
None listed