Multi-center Observation of the Natural Course of Inherited Retinal Dystrophies

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03691168

Acronym

RID

Enrollment

500

Registered

2018-10-01

Start date

2018-06-01

Completion date

2023-05-30

Last updated

2018-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inherited Retinal Dystrophies

Keywords

Inherited retinal dystrophies, Gene screen

Brief summary

Based on a clinical multi-center study of the natural course of inherited retinal dystrophies in Chinese population, screening fundus imaging indicators for patients with Chinese inherited retinal dystrophies, describing the clinical features of Chinese patients with inherited retinal dystrophies, and establishing a diagnosis of hereditary retinal diseases - Follow-up norms; establish a network-based multi-center diagnosis and follow-up platform; obtain a biological sample library of hereditary retinal diseases mainly in China. The research will further improve and enrich the genotype, phenotypic characteristics and natural course of Chinese inherited retinal dystrophies, in order to promote the clinical evaluation of clinical inherited retinal dystrophies and the standardization of genetic diagnosis. It is also the evidence for the best timing for future gene therapy, to obtain the best therapeutic effect, and to provide a theoretical basis for achieving precise treatment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

4 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. Patients with IRDs whose mutations have been identified 2. 4\ 70 years old 3. Complete 4 basic examinations of the eye: Corrective vision; fundus photography; OCT; ERG

Exclusion criteria

1. Has participated in other interventional treatment studies; 2. Patients with severe systemic diseases, mental dysplasia, mental illness; 3. Unable to accept eye examination patients; 4. Traumatic retinopathy, retinal inflammatory disease, paraneoplastic retinopathy, drug toxicity, and rare diseases such as diffuse unilateral subacute optic retinitis 5. At the initial visit, the patient's binocular vision is displayed as no light. 6. Both eyes have a history of internal eye surgery

Design outcomes

Primary

Measure	Time frame	Description
Visual acuity	60 months	A typical Snellen chart that if frequently used for visual acuity testing

Countries

China

Contacts

Primary Contacthuixun Jia, Master

jiahuixun@163.com+86 18017317575

Backup ContactWenqiu Wang, PHD

wangwenqiu@126.com+86 13817062881

Outcome results