Effect of Topical Dexmedetomidine on Intraocular Pressure

The Effect of Topical Dexmedetomidine (0.0055%) on Intraocular Pressure in Healthy Eyes: a Randomized Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03690622

Enrollment

Registered

2018-10-01

Start date

2017-12-01

Completion date

2018-04-03

Last updated

2018-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Intraocular Pressure

Brief summary

Evaluate the short-term safety and efficacy of dexmedetomidine (0.0055%) drops on intraocular pressure (IOP) in healthy eyes.

Interventions

DRUGDexmedetomidine

Instillation of eyedrops

DRUGBalanced salt solution

instillation of eyedrop

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Masking description

masking for the drop instilled

Intervention model description

randomised control trial

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients with healthy eyes and no history of glaucoma

Exclusion criteria

* history of glaucoma, IOP \> 24mmHg at baseline, abnormal optic nerve on fundus examination, keratoconus, corneal graft, corneal edema or a history of refractive surgery

Design outcomes

Primary

Measure	Time frame	Description
Intraocular pressure change	at presentation, 30 minutes, 4 hours and 24 hours after instillation	Taken by aplanation tonometry

Countries

Lebanon

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026