Thyroid Surgery
Conditions
Keywords
neuromonitoring, thyroid surgery
Brief summary
This study was designed to compare two dosage of sugammadex after tracheal intubation for optimal condition of continuous intraoperative neuromonitoring in thyroid surgery to protect recurrent laryngeal nerve.
Detailed description
Vocal cord paralysis is not a rare complication in thyroid surgery. Nerve monitoring technique has been developed, and many clinicians use the technique for saving the concerned nerves. Many studies showed that the effect of sugammadex on reverse of neuromuscular blocking after tracheal intubation. However, optimal dosage was not founded for sugammadex. This randomized controlled trial is to compare 1 mg/kg and 2 mg/kg as dosage of sugammadex for optimal continuous intraoperative neuromonitoring in thyroid surgery to prevent vocal cord paralysis.
Interventions
1 mg/kg or 2 mg/kg intravenous injection for each group (1 mg/kg group, 2 mg/kg group) after tracheal intubation
Sponsors
SMG-SNU Boramae Medical Center
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patients who need to open thyroid surgery
Exclusion criteria
* Who doesn't agree to enroll * Who has to receive other drug rather than rocuronium for muscle relaxant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of signal of neuromonitoring | intraoperative | During operation, surgeon evaluate the quality of signal of neuromonitoring on the basis of NIM III device. |
Countries
South Korea
Outcome results
None listed