A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03687567

Enrollment

737

Registered

2018-09-27

Start date

2013-09-01

Completion date

2020-12-31

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalassemia,Embryonic Development,Reproductive Sterility and Infertility

Brief summary

Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported. This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.

Interventions

PROCEDUREPreimplantation genetic diagnosis

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* infertility couples with thalassemia(one or both ) * infertility couples treat by PGD

Exclusion criteria

* abortion of amplification for blastula biopsy * PGD without diagnostic results or with unclear diagnostic results * embryos with both HBA and HBB genetic defect

Design outcomes

Primary

Measure	Time frame	Description
Gardner grading of blastocysts	embryo cultured in-vitro for 5-7 days	development status of blastocysts

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026