Endometrial Receptivity;RNA; Progesterone
Conditions
Keywords
endometrial receptivity, RNA, progesterone
Brief summary
to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window
Interventions
DRUGProgesterone
Different routes of administration of progesterone; Whether there is endometriosis
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal. control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal 2. progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40
Exclusion criteria
Patients with medical complications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endometrial receptivity measured by pathology | 3 months | 35 samples will be measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| endometrial receptivity measured by immunohisochemistry | 3 months | 35 samples will be measured |
| endometrial receptivity measured by Ribose Nucleic Acid （RNA） | 3 months | 35 samples will be measured |
| endometrial receptivity measured by scanning electron microscope | 3 months | 35 samples will be measured |
Countries
China
Outcome results
None listed