Attachment Loss, Periodontal, Cleft Lip and Palate, Periodontal Pocket
Conditions
Keywords
Inflammation, Healing, Distraction, Periodontium
Brief summary
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
Detailed description
Segmental forward maxillary distraction osteogenesis(DO)was performed. Distractor connecting buccal molar segments to the anterior maxilla was kept for 7 days. Then distraction was performed till overcorrection and consolidated for 3-months. Periodontal clinical parameters were recorded at baseline, 3 and 6-months postoperatively. Gingival crevicular fluid was collected . Soft tissue healing was evaluated clinically and histologically after distraction.
Interventions
PROCEDUREA Involvement with the osteotomy site of the surgery
A Involvement with the osteotomy site of the surgery
Sponsors
Alexandria University
University of Alexandria
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
The clinical assessment was not masked , however, the histological and biomarker examination were send to blind investigator not directly involved in the study
Intervention model description
Surgical distraction was performed in 20 cleft lip and palate (CLP) subjects with class III malocclusion, gingival GCF were collected from teeth neighboring the osteotomy site and from premolars of the opposite arch as control.
Eligibility
Sex/Gender
ALL
Age
16 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Severe maxillary hypoplasia and negative anterior overjet
Exclusion criteria
* Systemic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of periodontal inflammatory mediators | 7 days | periodontal inflammatory mediators IL-1β |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of periodontal inflammatory mediators TNF- α | 7 days | periodontal inflammatory mediators TNF- α |
| Assessment of periodontal probing depth | 3 and 6 month | probing depth measurement |
| Assessment of clinical attachment loss | 3 and 6 month | clinical attachment loss measurement |
| Assessment of periodontal clinical parameters | 3 and 6 month | Gingival index evaluation GI |
Other
| Measure | Time frame | Description |
|---|---|---|
| Evaluating the gingival histological changes | 2 and 4 weeks | histological examination of the soft tissue |
Countries
Egypt
Outcome results
None listed