Cystic Fibrosis, Respiratory Infection
Conditions
Keywords
Expectoration, Cystic Fibrosis, Nasopharyngeal, Viral molecular diagnosis
Brief summary
The aim of this pilot study is to demonstrate the feasibility of viral biomolecular diagnosis in sputum compared to nasopharyngeal swab in cystic fibrosis acute respiratory infection.
Detailed description
In cystic fibrosis (CF), patients face polymicrobial airway infections. Besides bacteria, viruses are now also considered as important agents in lung function deterioration. No strategy has been established on the optimal sampling for respiratory viral molecular diagnostic in CF. Nasopharyngeal swabs (NP) are recommended for respiratory viral screening in non-CF patients but are invasive and sometimes painful for patients. As sputa are non invasive and collected for bacterial monitoring in CF patients they could represent a convenient alternative to NP swabs. This study's aim is to define whether viral screening give concordant results between sputa and NP swabs.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Participant with Cystic Fibrosis * Participant able to expectorate * Participant with sign of acute respiratory infection
Exclusion criteria
* participant not able to expectorate * patient refusing to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concordance of viral type detected in both samples for each participant: sputum and nasopharyngeal swab | Day 1 | Comparison of per participant results of viral molecular detection in sputum and nasopharyngeal swab. Concordance=same virus(es) or no virus detected in both sample. no concordance=different viruses detected in each sample or virus(es) detected in only one sample and not in the other |
Countries
France
Outcome results
None listed