Aging, COPD
Conditions
Brief summary
Verify the influence off vitamin D supplementation and a whole body vibration (WBV) protocol during 03 months in older patients chronic obstructive pulmonary disease
Interventions
DIETARY_SUPPLEMENTVitamin D
a dose once a week
03 months of WBV training three times per week
Sponsors
Maíra F Pessoa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Older patients with COPD * Both genders * Sedentary according to International Physical Activity Questionnaire (IPAQ) short form * BMI in between 22.9 and 28 kg/m2. * Older patients with COPD should have a clinical-functional diagnosis of the disease according to GOLD (GOLD, 2018), have been ex-smokers and have not used corticosteroids or have used this drug in a stable way for at least one year (without dosage or medication modifications). * Older volunteers should be self-referenced healthy or, if they had systemic arterial hypertension or diabetes mellitus, these comorbidities should be controlled by diet or regular medication use.
Exclusion criteria
* Older patients with COPD who had episodes of exacerbation in the last three months, those with pulmonary rehabilitation programs in the last year, those who used home oxygen therapy, and patients with COPD associated comorbidities were excluded. * Volunteers of both groups who were taking vitamin D were excluded, as well as the current smokers, although occasional, volunteers with a history of labyrinthitis or thromboembolism, who had undergone surgical procedures of any size in the last year, such as plaques, pins or cardiac pacemakers, those with unconsolidated fractures that used medications that affected bone metabolism or lean mass, or those who had difficulties adapting to the assessment or the training protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum inflammatory marker Interleukine-6 (IL-6) | before and immediately up to 12 weeks in WBV training. | changes in total serum values of interleukine 6 |
| serum inflammatory marker Interleukine-8 (IL-8) | before and immediately up to 12 weeks in WBV training. | changes in total serum values of interleukine 8 |
| serum inflammatory marker TNF-alpha ( and BDNF) | before and immediately up to 12 weeks in WBV training. | changes in total serum values of tumoral necrose factor alpha |
| serum inflammatory marker and brain derived neurotrophic factor (BDNF) | before and immediately up to 12 weeks in WBV training. | changes in total serum values of brain derived neurotrophic factor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | before and immediately up to 12 weeks in WBV training. | Changes in electrical bioimpedance assessing lean mass in segmental areas and trunk |
| Respiratory strength | before and immediately up to 12 weeks in WBV training. | Changes in respiratory strength obtained from a manovacuometer, collecting the major value of 03 maneuvers of the maximal inspiration (vacuometer) to the maximal expiration pressures (manometer), with values obtained in centimeters of water |
| Peripheral strength | before and immediately up to 12 weeks in WBV training. | Changes in Peripheral muscle strength assessed by the hand dynamometer (device that assess strength) in values obtained from the mean of 03 maneuvers of isokinetic contraction, in centimeters of water |
Countries
Brazil
Outcome results
None listed