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Hemodynamic Effects of Ventilation Modes

Effects of Two Different Ventilation Modes Used in Gynecologic Laparoscopic Operations Performed in Steep Trendelenburg Position on Hemodynamic Parameters

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03684291
Enrollment
30
Registered
2018-09-25
Start date
2018-10-01
Completion date
2018-11-15
Last updated
2018-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamics, Laparoscopy, Respiration, Artificial

Keywords

Mechanical ventilation, Laparoscopic surgery, Hemodynamics

Brief summary

Different ventilation modes can be used in laparoscopic surgeries. These surgeries are performed in steep Trendelenburg position with serious hemodynamic disturbances. This study aims to observe the hemodynamic effects of two different ventilation modes in laparoscopic gynecologic surgery performed in steep Trendelenburg position.

Interventions

PROCEDUREMode of Mechanical Ventilation

Adjustment of mechanical ventilation mode

Sponsors

Ufuk University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Women of ASA I and II classification between 18-65 years scheduled for elective gynecologic laparoscopic surgery

Exclusion criteria

* Patient refusal to participate * Patients with severe cardiac (congestive heart failure etc) and pulmonary (COPD, pulmonary hypertension) disease (ASA \> III) * Morbid obesity * Negative Allen test

Design outcomes

Primary

MeasureTime frameDescription
Measurement of changes in aortic dp/dtT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationAortic dP/dt (mmHg/msec)
Measurement of changes in cardiac indexT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationCardiac index L(min x m2)
Measurement of changes in stroke volume variationT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationStroke volume variation (%)
Measurement of changes in cardiac cycle efficiencyT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationCardiac cycle efficiency (units)
Measurement of changes in MAPT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationMean arterial pressure (MAP) (mmHg)
Measurement of changes in heart rateT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationHeart rate (bpm)
Measurement of changes in systemic vascular resistance indexT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationSystemic vascular resistance index (dyne x sec/cm2)
Measurement of changes in stroke volume indexT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationStroke volume index (mL/m2)

Secondary

MeasureTime frameDescription
Measurement of changes in mean airway pressureT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationPmean (Mean Airway Pressure),
Measurement of changes in plateau airway pressureT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationPplateau (Plateau Airway Pressure)
Measurement of changes in peak airway pressureT0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflationPpeak (Peak airway pressure)

Countries

Turkey (Türkiye)

Contacts

Primary ContactPerihan Ekmekçi, MD
erdogduperi@gmail.com+903122044000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026