Brain Tumor, Glioma, Malignant Glioma, Malignant Primary Brain Tumor, Primary Brain Tumor
Conditions
Keywords
Non-invasive glioma characterization, Molecular Imaging, Isocitrate Dehydrogenase (IDH) Mutations, MRI-Based Sequencing
Brief summary
MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.
Detailed description
This is a pilot study aiming at developing and optimizing MRI-based sequences to provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.
Interventions
DEVICE3T MRI Scanner
3T MRI Scanner providing Mega-laser sequence for single-voxel Magnetic Resonance Spectroscopy (MRS) data for 2 hydroxyglutarate (2HG) quantitation.
Sponsors
University of Miami
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (≥18 year old) * Subjects with suspected or confirmed gliomas and who will have a medically indicated biopsy or resection of his/her brain lesion.
Exclusion criteria
* Adults unable to consent * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Patients unable to have MRI done
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 2HG Concentration via 3T MRI Scanner | Day 1 | 2HG concentrations as measured via 3T MRI Scanner. |
| 2HG Concentration from tissue samples | Day 1 | 2HG concentrations as measured via patient's surgically excised tissue sample ex vivo by tissue based liquid chromatography-mass spectrometry (LC-MS) |
Countries
United States
Contacts
CONTACTNathalie Padron
PRINCIPAL_INVESTIGATORMacarena De La Fuente, MD
University of Miami
Outcome results
None listed