Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Mining the Urinary and Serum Metabolome for Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03683654

Enrollment

494

Registered

2018-09-25

Start date

2012-04-26

Completion date

2013-02-23

Last updated

2018-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Exposure

Brief summary

This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.

Detailed description

Subjects participating in the study are characterized by the availability of one 24-hr urine sample, blood serum, 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ) data. The main objectives of the proposal are: 1. To collect a set of high-quality metabolomic data containing rich information on the food-derived metabolome. 2. To mine this data in different Metabolome-Wide Association Studies in order to identify food-derived metabolites discriminating consumers and non-consumers of various foods, nutrients and dietary patterns. 3. To identify the food-derived metabolites characteristic of the consumption of the different foods/nutrients and dietary patterns.

Interventions

OTHERIdentify Biomarkers of Dietary Intake in Healthy Subjects

Observational study. No intervention.

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged 30-70 * Healthy * Residing within Europe. * Have donated one 24-hr urine sample, blood serum. * Have filled one 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ).

Exclusion criteria

* 24-hr urine sample and 24-hr dietary recall not collected on a same day. * Incomplete collection of 24-hr urine sample.

Design outcomes

Primary

Measure	Time frame	Description
Metabolite concentrations in plasma and urine	1 day	Food-derived Metabolite concentrations in plasma and urine are measured by high resolution mass spectrometry coupled to ultrahigh performance chromatography.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026