Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03683537

Enrollment

Registered

2018-09-25

Start date

2018-02-15

Completion date

2021-12-15

Last updated

2025-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Astrogliosis, Postoperative Cognitive Dysfunction, Postoperative Delirium

Brief summary

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Interventions

DIAGNOSTIC_TESTGlial fibrillary acidic protein

3 samples of serum are drawn from patients. The 1st Sample of patient serum is drawn before induction into anesthesia. The 2nd is drawn 24 hours after the 1st one. The 3rd sample is drawn on 3 or 4 postoperative day. All samples collected and preserved in the same temperature as required for ELISA.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with different diseases, who require prolonged laparoscopy or open surgery * Age more than 60 * ASA I-III * Informed consent to participate in the study

Exclusion criteria

* ASA IV-V * Severe neurodegenerative or psychological diseases

Design outcomes

Primary

Measure	Time frame	Description
Changes in serum GFAP	1 year	GFAP(3) - GFAP (1); GFAP (2) - GFAP (1)

Countries

Russia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026