Body Composition, Hidradenitis Suppurativa, Mediterranean Diet, Trimethylamine N-oxide (TMAO), Vitamin D Deficiency
Conditions
Brief summary
Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.
Interventions
DIETARY_SUPPLEMENTMediterranean Diet
We aim to determine the effects of the traditional Mediterranean Diet on Hidradenitis suppurativa
Sponsors
Federico II University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects of both gender * treatment-naïve patients * had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months
Exclusion criteria
* occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics; * hypocaloric diet in the last three months or specific nutritional regimens; * vitamin/mineral or antioxidant supplementation; * occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adherence to Mediterranean Diet by Predimed Questionnaire | April 2015 to April 2018 | Validated 14-item tool of adherence to the Mediterranean diet, with three categories of adherence (≤5, low adherence, 6-9, average adherence and ≥10 points, high adherence) |
| Phase angle | April 2015 to April 2018 | Phase angle was performed using a BIA phase-sensitive system by experienced observers (an 800-µA current at a frequency single-frequency of 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy). |
| Trimethylamine N-oxide plasma levels | April 2015 to April 2018 | ultra high-performance liquid chromatography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D | April 2015 to April 2018 | 25 OH vitamin D assay for the LIAISON automated analyzer |
Outcome results
None listed