Chronic Renal Disease
Conditions
Keywords
Chronic Renal Disease, Nail fold microcirculation, Interventional therapy
Brief summary
To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy
Detailed description
The aim of this study is to study the changes of Nailfold Microcirculation in patients with chronic renal failure, to clarify the correlation between the changes of Nailfold Microcirculation and renal function, and to explore whether nailfold microcirculation can be used as an indicator of renal microcirculation in patients with chronic renal failure, and to provide a noninvasive method for the clinical evaluation of renal microcirculation in patients with chronic renal failure.
Interventions
Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks.
Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks ,then they take beraprost sodium tablets 40ug orally three times perday for 3 months.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* CKD patients * Without dialysis * Blood pressure ≤ 140/90mmHg
Exclusion criteria
* Polycystic kidney * Endocrine system disease * Cardio-cerebrovascular disease * Rheumatic immune disease * Peripheral vascular disease * Hematological diseases * Respiratory disease * Infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nailfold microcirculation morphological integral | Up to three and a half months | Nail fold capillary microscopy examination |
| Nailfold microcirculation blood flow integral | Up to three and a half months | Nail fold capillary microscopy examination |
| Nail fold microcirculation perivascular loop integral | Up to three and a half months | Nail fold capillary microscopy examination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| eGFR | Up to three and a half months | Intravenous blood sampling |
| The content of blood albumin | Up to three and a half months | Intravenous blood sampling |
| The content of blood serum creatinine | Up to three and a half months | Intravenous blood sampling |
| The content of hemoglobin | Up to three and a half months | Intravenous blood sampling |
| The quantification of urinary protein | Up to three and a half months | Uronoscopy |
| The content of blood urea nitrogen | Up to three and a half months | Intravenous blood sampling，uronoscopy |
| The content of blood cystatin C | Up to three and a half months | Intravenous blood sampling |
Countries
China
Outcome results
None listed