OCD
Conditions
Brief summary
Obsessive-compulsive disorder (OCD) is a severe mental illness characterized by repetitive behaviors that a person feels compelled to perform. It has been demonstrated that stimuli in the environment can trigger the compulsive urge, perpetuating the OCD cycle. The main goal of the current proposal, which is based on exciting pilot data, is to test a novel computerized training program to create an association between OCD-related stimuli, which typically trigger the compulsive urge, and the brain system responsible for stopping. The idea is that once this system is triggered, it will be easier for patients to stop the compulsive urge.
Interventions
BEHAVIORALP-CIT protocol
Personalized inhibitory control training for one week.
BEHAVIORALPlacebo
without personalized inhibitory control training for one week.
Sponsors
Hebrew University of Jerusalem
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* OCD patients
Exclusion criteria
* Metal/ electronic device * Under the age of 18 * Pregnant women * Tattoos that cover over 10% of body mass * Chronically ill patients * Psychosis/ Bi-polar * Substance abuse * Sever depression * Active suicide thoughts * Hearing loss
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI- changed inhibition levels in the pre-SMA area in experimental group in comparison to control group | One week after P-CIT training starts | During tasks that require inhibition |
| fMRI- changed inhibition levels in the rIFG area in experimental group in comparison to control group | One week after P-CIT training starts | During tasks that require inhibition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavioural- Y-bocs (Yale-Brown Obsessive-Compulsive Scale) score- change in OCD symptoms in experimental group in comparison to placebo group | One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training | Clinical assessment. Semi-structured interview that assesses the presence and severity of obsessions and compulsions over the past week. The 5-item Obsession Severity and Compulsion Severity subscales are summed to produce a Total Severity score. Symptoms endorsed are rated on a scale from none (0) to extreme (5). The 5-item Obsession Severity and Compulsion Severity subscales are summed to produce a Total Severity score. |
| Behavioural- M.I.N.I (Mini-International Neuropsychiatric Interview) score- change in OCD symptoms in experimental group in comparison to placebo group | One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training | Clinical assessment. Structural interview. |
| Behavioural- OCI-R (Obsessive-Compulsive Inventory) score- change in OCD symptoms in experimental group in comparison to placebo group | One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training | Clinical assessment. Cutoff score of 21 is distinguish individuals with OCD from those without anxiety disorders. |
Countries
Israel
Contacts
Primary ContactShahaf Leshem, B.A.
Outcome results
None listed