Validation of Low Dose CT for Diagnosis of Lung Nodules

Validation of an Extremely Low Dose Computed Tomography Protocol for Diagnosing Lung Nodules in Children and Young Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03681873

Enrollment

Registered

2018-09-24

Start date

2018-11-30

Completion date

2021-09-07

Last updated

2022-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer, Metastasis to Lung

Brief summary

The investigators have developed an extremely low dose computed tomography (CT) protocol that on preliminary testing has an effective dose in the range of two chest radiographs. The investigators plan to test this exam in patients with known or suspected cancer undergoing clinically indicated chest CT.

Interventions

DIAGNOSTIC_TESTExtremely Low Dose CT

Patients undergoing a clinically indicated chest CT will also undergo the extremely low dose CT

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

4 Years to 20 Years

Healthy volunteers

Inclusion criteria

* Pediatric and young adult patients (ages 4 to \<21 years) * Known or suspected malignancy other than lymphoma * Undergoing clinically indicated CT of the chest

Exclusion criteria

* Pregnancy identified by routine Department of Radiology verbal screening * Prior enrollment in the same study (no patient will be enrolled more than once) * Inability to provide consent and/or assent * Lymphoma

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic performance of extremely low dose CT	At time of imaging	Sensitivity

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026