A Study on the Pain Control Effect of the Anesthetic Method During Prostate Biopsy: Comparison Between Pelvic Plexus Block and Periprosthetic Nerve Block

What is the Most Effective Local Anesthesia for Prostate-stained Ultrasonography-guided Biopsy in PPB and PNB?: A Single Center, Prospective, Randomized, Double Arm Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03681522

Enrollment

Registered

2018-09-24

Start date

2018-09-10

Completion date

2019-04-30

Last updated

2018-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transrectal Systematic Prostate Biopsy Related Pain

Keywords

local anesthesia, prostate, biopsy, transrectal

Brief summary

This study assesses differences in the effects of pelvic plexus block and periprostatic nerve block among various anesthetic methods that reduce the pain caused by prostate biopsy.

Detailed description

Recently, various types of local anesthetic methods have been attempted to reduce biopsy-related pain leading to changes in the type of anesthetic agents and site of injection. Of these anesthetics and combinations, pelvic plexus block and periprostatic nerve block seem to be the very effective way to control prostate biopsy-related pain. However, few studies have compared these two methods.

Interventions

PROCEDUREPelvic plexus block

Injections of 2.5 mL of 2% lidocaine were made to the pelvic neurovascular plexus located at the end of the seminal vesicle under Doppler US guidance on each side

PROCEDUREPeriprostatic nerve block

Injections of 2.5 mL of 2% lidocaine were made to the neurovascular bundles at the junction of the prostate-bladder-seminal vesicle on each side.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* abnormal prostate finding on digital rectal examination * serum PSA level of \> 2.5 ng/mL * Transrectal ultrasonographic abnormal lesion

Exclusion criteria

* under 50 years old * a history of previous TRUS-guided biopsy * chronic prostatitis/pelvic pain * neurological conditions (dementia, Parkinson disease, or cerebral infarction) * bleeding diathesis * active UTI * hemorrhoids/anal fissure/anal fistula * known allergy to lidocaine

Design outcomes

Primary

Measure	Time frame	Description
Visual analog scale-4	day 7~14	Visual analog scale (0-10) at 15 min after the biopsy procedure higher values represent a worse outcome.
Visual analog scale-1	day 7~14	Visual analog scale (0-10) during anesthesia procedure higher values represent a worse outcome.
Visual analog scale-2	day 7~14	Visual analog scale (0-10) at insertion of ultrasound probe higher values represent a worse outcome.
Visual analog scale-3	day 7~14	Visual analog scale (0-10) during biopsy procedure higher values represent a worse outcome.

Secondary

Measure	Time frame	Description
Rate of Complication	day 14~28	Complications after biopsy
Procedure time	day 7~14	Total time taken for prostate biopsy

Countries

South Korea

Contacts

Primary ContactKangSu Cho, MD., PhD.

kscho99@yuhs.ac+8220193470

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026